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1291 results found

Role of potassium channel opener in salicylate induced tinnitus

The exact mechanism in the origin of tinnitus is not known. Many pharmacological agents have been tried to to treat tinnitus without great success. Aspirin is a commonly used medicine in the elderly population to reduce the risk of stroke...

Chronic cough hypersensitivity syndrome

We all have patients who give us a ‘heartsink’ feeling; for many of us, the coughing patient is exactly such a situation. In this overview, Bhaskar Ram and Sangeeta Maini outline their approach to diagnosis. Declan Costello, Editor. Introduction Chronic...

What’s new in protecting hearing?

Preventing an avoidable hearing loss before it begins would be the public health dream. In this article Kathleen Campbell takes us through one option that is showing the potential to fulfil that ambition. Kathleen explains the development of a preventative...

Systemic agents in thyroid cancer

For those patients who have disseminated or unresectable thyroid cancer, Dr Arabella Hunt and Dr Kate Newbold review systemic treatments, their differences, toxicities and outcomes. Thyroid cancer is the most common endocrine malignancy. It is subdivided into differentiated (papillary, follicular...

Targeting the microbiome in chronic rhinosinusitis

Researchers at St Paul’s Sinus Centre and UBC in Vancouver are testing a novel treatment for CRS: transferring mucus from a healthy donor into a patient’s sinuses. Chronic rhinosinusitis (CRS) is one of the most common diseases managed by otolaryngologists...

A single blinded RCT comparing triamcinolone with 5-FU treatment for keloid scars

This single blinded RCT compared 43 patients with 50 symptomatic keloids that were randomised to two matched groups of 25 scars, receiving either 5-fluorouracil (5-FU) or current first line treatment, triamcinolone (TAC). The surgeon administering the injectable treatments was unblinded,...

The changing landscape for hearing loss therapeutics: novel advances of gene and cell therapies

Recent years have seen advances in hearing loss therapeutics, with novel treatments trialled in humans, and others nearing promising first-in-kind clinical trials. First successful clinical trials for a specific form of genetic hearing loss Very exciting news has emerged in...

Cochlear implant referral: how can we do better?

Considerable progress has been made over the last few years in improving access to cochlear implantation (CI) in the UK for children and adults with severe to profound deafness. But we are still not treating children early enough, and we...

Is a hemithyroidectomy as effective as a total thyroidectomy for compressive symptoms?

The claim made in the title of this paper, that hemithyroidectomy is equally as successful as total thyroidectomy in alleviating compressive symptoms from goitres, is certainly intriguing. And with the inclusion of 45,539 subjects, it would at first glance seem...

Robot controlled mastoid surgery!

This is a fascinating piece of work by a Korean team developing a human-robot collaborative control. Their model uses image guidance surgery to locate the drill tip’s position. Important structures can be highlighted – in this case the facial nerve....

Tranexamic acid and blood loss in bimaxillary surgery

This is a randomised double-blind placebo-controlled trial from Thailand to clarify the most effective dose of Tranexamic acid in reducing blood loss during a bimaxillary osteotomy. They confirmed that the dose of 10mg per kg is the most efficacious and...