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Investigation of the role of KPNA2 biomarker in oral SCC invasiveness
This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...
Cochlear implantation in children with congenital long QT syndrome
Jervell and Lange-Neilsen syndrome is a condition where sensorineural deafness coincides with inherited abnormalities of the heart, resulting in prolonged ventricular repolarisation, frequently shown on an ECG with a prolonged QT interval. These children can present at implant centres for...
Peripheral nerve stimulation for chronic refractory pain
Peripheral nerve stimulation (PNS) plays an important role in treating chronic refractory pain syndromes that manifest in limited distributions and overlap with areas of neurologic innervation. The process is generally thought to capitalise on the inhibition and activation of pain-related...
OSA – do the parents know best?
The difficulty in using the history and examination to determine the severity of sleep disordered breathing in children is well established. The relative prevalence of sleep disordered breathing symptoms in children, and the relative paucity of capacity and restrictive cost...
Pharmacologic treatment options for tinnitus
This article summarises potential medications that could be used to treat tinnitus and the evidence behind their use. Effective medications to eliminate tinnitus remain elusive but treatment could be divided into two broad categories: treatment to reduce perception of tinnitus...
All videoswallows are not performed equally…
Videofluoroscopy is one of the main instrumental tools used to assess swallowing biomechanics and physiology. In the UK, it is mainly within the remit of speech and language therapists (SLT) to perform videoswallows but there is considerable variability in both...
How common are swallowing problems in a general adult population?
This paper reports on the largest cross-continent study to date, looking at the prevalence of swallowing problems reported by adults in the community aged 18-65 years old. The authors used the Eating Assessment Tool (EAT-10) distributed via an online survey...
Can SNOT-22 predict the need for surgery?
In this prospective Belgian study, the authors looked at whether the baseline Sino-Nasal Outcome Test-22 (SNOT-22) was able to predict the need for surgery and localise the pathology of rhinology patients and healthy volunteers. A total of 66 healthy volunteers...
Global incidence of sporadic vestibular schwannoma
The incidence rate of sporadic vestibular schwannoma (VS) has commonly been quoted as one in 100,000. However, since the advent of screening for asymmetrical hearing loss and increased availability of modern MRI scanning, more recent studies have shown the incidence...
Is it beneficial for children to undergo bilateral cochlear implantation before 12 months old?
Universal newborn hearing screening has allowed early diagnosis and, subsequently, early intervention in hearing loss. In 2020 the Food and Drug Administration candidacy criteria for cochlear implants (CI) expanded to include profound sensorineural hearing loss (HL) in children as young...
How best can we manage Samter’s Triad/AERD?
The classic ‘Samter’s Triad’ of asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and aspirin sensitivity is now referred to as aspirin-exacerbated respiratory disease (AERD) or non-steroidal anti-inflammatory-exacerbated respiratory disease. We often come across in our rhinology setting, patients with recalcitrant...
