The use of codeine in the paediatric population is widely debated since the American Food and Drug Administration (FDA) published warnings regarding overdose and death following the usage of codeine. Codeine is metabolised by the polymorphic cytochrome PY4502D6 (CYP2D6) in...
In 2001 a survey was conducted in a number of towns across the world, including Exeter in the UK, to identify the level of awareness and knowledge of aphasia in the community. Aphasia is difficulty in producing or understanding language...
With the arrival of flexible fibreoptic laryngoscope some 35 years ago, the examination of the laryngopharynx has become remarkably easier and saves immense time and costs since the days of mirror examination when this examination was not truly satisfactory in...
The Irish implant centre in Dublin undertook a retrospective study of their reimplantation cases to look at what lessons could be learnt. Device failures fall into two classes: hard and soft failures. Hard failures are implant malfunction or altered performance....
This is a French single-centre, 10-year experience of 55 surgical resection and reconstruction procedures. They claim an overall effectiveness rate of 92.3%. A total of 36 segmental and 19 marginal mandibulectomies were performed. A variety of free flaps were used,...
The authors of this article highlight that the number of older people has increased significantly in the last two decades, and the number of people over 85 has doubled in Australia since 1996. They attribute this to improved lifestyle factors...
Delivering healthcare interventions remotely is not a new concept. The authors of this article provide a brief history dating back to the 1930s, when the International Radio Medical Centre was established to transmit medical advice to global seafarers. In the...
Most healthcare professionals will have had to dabble in using some kind of telehealth platform over the last 18 months or so. And most of us will have had some reservations, or have colleagues who just weren’t sure about Zoom,...
In this study, the authors retrospectively compare hearing outcomes after mastoid obliteration to non-obliterative techniques in cholesteatoma surgery. They have performed canal wall up with mastoid obliteration (bony obliteration tympanoplasty or BOT) since 2013. The procedure has replaced canal wall...
Cardiovascular disease (CVD) risk factors are associated with microvascular damage that can impair molecular transport across capillary walls and cause inflammation and oxidative stress that may damage cochlear structure and function. This study determined, among a population-based sample of Canadian...
Alport syndrome (AS) includes a group of hereditary diseases caused by mutations in the COL4A3, COL4A4 or COL4A5 genes. These genes are responsible for the biosynthesis of α3, α4 and α5 collagen IV chains, which are located in the glomerular...
From a sunny Southend, UK, Gareth Smith takes 10 minutes to dial into the Sunshine State, USA, and catch up with Tish Gaffney for a lightning-speed chat on the movements and motivations of the 35th president of the American Academy...