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ENT in this issue...Anaesthetics and ENT
Nick Crombie, BMedSci BMBS FRCA FIMC RCSEd RCPathME, Associate Medical Director (Governance); Consultant Trauma Anaesthetist; Honorary Researcher, National Institute for Health Research SRMRC: Clinical Lead for Resuscitation Services, QEHB, UK. E: Nicholas.Crombie@uhb.nhs.uk Plastic surgeons think we do endless crosswords. Orthopaedic...Tonsillitis and tonsillectomies: where do we go from Paradise?
Landmark Paper: Paradise JL, Bluestone CD, Bachman RZ, et al. Efficacy of tonsillectomy for recurrent throat infection in severely affected children – results of parallel randomized and nonrandomized clinical trials. N Engl J Med 1984;310(11):674-83. The Paradise paper on tonsillectomy...Precision and personalised genomic and epigenomic medicine in audiology/hearing loss
A detailed look at the pathogenesis of acquired hearing loss due to exposure to ototoxicity during pregnancy or shortly after birth. Insights from genomic medicine have shown that, along with environmental factors causing epigenetic alterations, hearing loss may be caused...Acupuncture for tonsillectomy pain in children
The challenge: tonsillectomy pain Tonsillectomy is a uniform surgical insult which results in a 10-day recovery for children. Severe pain can occur which can give rise to poor oral fluid intake, dehydration and potentially the need for intravenous fluid resuscitation....
The future of biologics?
This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...
Zinc and rhinosinusitis
Patients with chronic rhinosinusitis (CRS) in general, and those with nasal polyps (CRSwNP) in particular, have been shown to have down-regulation of tight junction genes. Zinc, on the other hand, is well-known for its role in immune regulation and deficiency...
Precision medicine in allergic rhinitis and chronic rhinosinusitis
Precision medicine (PM) with its ‘four Ps’ (personalised, predictive, preventive and participatory) is about appreciating differences between individuals when offering management options for health problems. Multiple groups interested in rhinology such as EPOS and ARIA supported a review of the...
What blood tests should be requested to investigate vocal cord paralysis?
Patients who are discovered to have a vocal cord palsy with no obvious cause on history or examination routinely undergo investigations to exclude an underlying pathology. Cross-sectional imaging of the relevant recurrent laryngeal nerve is required, but considerable variability has...
Biopsy sites with a diagnosis of pemphigusand mucous membrane pemphigoid
This is a systemic review and met-analysis to critically evaluate optimal biopsy site for patients presenting with pemphigus or mucous membrane pemphigoid. Historically, diagnosis is made if H&E staining direct immunofluorescence and serological testing of auto-antibodies. Direct immunofluorescence has been...
