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Genetic discovery using animal models: presbyacusis

By their very nature, late-onset hereditary disorders offer a large window of opportunity for therapeutic intervention. However, before we can begin to think about strategies we need knowledge of the genetics and pathology underlying the condition. In this article we...

Scientific advances in mapping syndromic hearing loss

From more than 22000 genes that we humans have, approximately 3000 genes are associated with human communication. There are tens of syndromes which have been identified to be accompanied by hearing loss. Disorders of almost every organ of the body...

Precision and personalised genomic and epigenomic medicine in audiology/hearing loss

A detailed look at the pathogenesis of acquired hearing loss due to exposure to ototoxicity during pregnancy or shortly after birth. Insights from genomic medicine have shown that, along with environmental factors causing epigenetic alterations, hearing loss may be caused...

Surgical management of sleep disordered breathing

Snoring and sleep-disordered breathing are often described as multi-level problems, and different surgical procedures are required to treat the various sites of airway narrowing and/or collapse. Jonathan Hobson gives us an eloquent run-through the various options available to the ENT...

Ronald G Macbeth – the instigator of BACO

The structure of BACO has changed dramatically since the first conference in 1963, but the fundamental elements of academic excellence, instructional sessions and social events have been common threads. Andrew Freeland, who worked with Ronald Macbeth, the instigator of BACO,...

Active middle ear implants and bone-anchored hearing systems

The implantable hearing device market has grown significantly over recent years. But as conventional hearing aids improve and cochlear implant candidacy widens, what is the role for active middle ear implants and bone anchored hearing systems, and how should we...

The James Lind Alliance – involving patients and their health professionals jointly in setting priorities for research

In a world of patient-reported outcomes and patient-centred care, patient-centred research must also be considered. That is where the James Lind Alliance (JLA) comes in, as Caroline Whiting explains below. Through Priority Setting Partnerships (PSPs), it allows patients, their carers...

Unpacking the World Health Organization’s World Report on Hearing: what does it say?

The inaugural report on hearing from the World Health Organisation is a tool for advocacy, and for getting hearing loss on government agendas. Nguyen Ngoc Bao Tran was 11 months old when her hearing loss was diagnosed. Despite being informed...

Unpacking the World Health Organization’s World Report on Hearing: what does it say?

The inaugural report on hearing from the World Health Organisation is a tool for advocacy, and for getting hearing loss on government agendas. Nguyen Ngoc Bao Tran was 11 months old when her hearing loss was diagnosed. Despite being informed...

SEQaBOO: SEQuencing a Baby for an Optimal Outcome

There are at least 15 countries now running genome sequencing projects. The team in Manchester, UK, and Boston, USA, share their SEQaBOO project. Abstract SEQaBOO (SEQuencing a Baby for an Optimal Outcome) will transform newborn hearing screening (NBHS) by bringing...