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One airway, one disease - not for everyone!
While 85% of asthmatic patients have rhinitis, only 20-30% with rhinitis have asthma. Together with atopic dermatitis (AD), rhinitis and asthma form a triad that tend to co-exist in patients (multimorbidity). This co-existence raises the possibility of genetic mechanism. Authors...
The future of biologics?
This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...
Motor learning: better knowing how, not how well
Motor learning is described as the ability to perform a motor skill due to practice and/or experience. Research on interventions to enhance limb motor skills can be influenced through the amount, distribution, variability and schedule of practice as well as...
An algorithm to distinguish between distant metastases and metachronous lung primary in patients with HPV-related oropharyngeal cancer
Distinguishing between distant metastases of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) and metachronous primary lung squamous cell carcinoma (SCC) is important as it has implications for treatment, prognosis counselling, and registry data. Although p16 immunohistochemistry (p16 IHC) is widely accepted...
Endoscopic Transnasal Anatomy of the Skull Base and Adjacent Areas
This book is a well-designed colour atlas of sinus surgery which is up to date with all the modern techniques used in endoscopic sinus surgery. The multiple authors include well-established and renowned surgeons. It is divided into distinct chapters, with...
Should we do oesophagoscopy during panendoscopy?
Panendoscopy entails a complete evaluation of the upper aerodigestive tract, and consists of oral inspection, direct laryngoscopy, bronchoscopy, oesophagoscopy, or some combination of these procedures. Despite many advances in imaging over the years, a skilled surgeon’s eyes remain superior in...
Rhinoplasty for the cleft lip and palate patient
The cleft nose is one of the most challenging pathologies for rhinologists and facial plastic surgeons to address. The combination of architectural deformity (related to the extent of lip deformity) and scarring from previous surgery combine to cause the surgical...
Submental island flap to reconstruct the lower lip
The lips are necessary for oral competence, cosmesis, speech and feeding. Non-melanoma cancers can affect the lips, and the lower lips are about 80% more likely to be affected. A large number of these cancers are squamous cell carcinomas. Treatment...
Cosmesis of the nose in cleft lip and palate
The cleft nose is one of the most challenging pathologies for rhinologists and facial plastic surgeons to address. The combination of architectural deformity (related to the extent of lip deformity) and scarring from previous surgery combine to cause the surgical...
The mark of the head and neck surgeon
Like Zorro, the head and neck surgeon leaves their mark. No more so than during parotid surgery. Various modifications have been put forward modifying the classic Blair incision. This latest modification camouflages the pre-tragal scar by running it on to...Microneedles enable inner ear precision medicine
Developing safe, reliable and efficient ways to deliver therapeutics into the cochlea is a key challenge. In this article, the authors share their work to develop microneedles to address this challenge. The era of precision medicine of the inner ear...
