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To montelukast or not to montelukast
Both histamine and cysteinyl leukotrienes play an important role in both seasonal allergic rhinoconjunctivitis (SARC) and asthma. A combination therapy against both was shown to give benefit both in vitro and in vivo. Authors wanted to test the efficacy of...
The polyp shrinker
Inflammatory markers, including T2 cells beta common (βc) cytokines IL-3, IL5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), are known to play an important role in chronic rhinosinusitis with nasal polyps (CRSwNP). CSL311, a monoclonal antibody (mAb), was developed to target human...
The hippo and the nose
Chronic rhinosinusitis with nasal polyps (CRSwNP) leads to histological changes including thickening of the basilar membrane and epithelial proliferation. Molecular mechanisms underlying these changes are still not fully clear. A signalling pathway called the hippo with Yes‐associated protein (YAP) as...
Hypoglossal nerve stimulation for OSA
Hypoglossal nerve stimulation has been lauded as the great new surgical treatment panacea for obstructive sleep apnoea (OSA). This meta-analysis includes 12 studies with a total of 350 patients, including the five-year follow-up data from the STAR trial which was...
Diagnostic criteria for haemodynamic orthostatic dizziness
Over the past several years, the Bárány Society has been developing an International Classification of Vestibular Disorders (ICVD) in order to standardise diagnosis and nomenclature for both clinical and research purposes. Many in vestibular practice would be familiar with the...
Sphenopalatine ganglion block in endoscopic sinus surgery reduces intra and post-operative morbidity
The authors present results of a meta-analysis to investigate the role of sphenopalatine ganglion block (SPGB) in reducing postoperative pain in endoscopic sinus surgery (ESS). An electronic database search (Pubmed, SCOPUS, Google Scholar, Embase, and the Cochrane Register of Controlled...Minimise waiting times with Peptest!
In laryngopharyngeal reflux (LPR), refluxed stomach contents travel up the oesophagus and reach the larynx, causing chronic extra-gastrointestinal symptoms such as a persistent cough, hoarseness or difficulty swallowing, meaning it is often attributed to ENT problems.
The power of (younger versus older) lips
The Directional into Velocity of Articulators (DIVA) model theorises that we require both auditory and sensory feedback - from our articulators - in order to ensure we are able to produce precise and powerful articulatory movements. This study aimed to...
The ‘My Hearing Explained’ tool: audiologist and client perceptions
The study notes that the pure tone audiogram has been the primary clinical and counselling tool used by clinicians to assess and describe hearing thresholds to individuals and families since 1922. The Ida Institutes, ‘My Hearing Explained’ tool has become...
What is the quality of patient-reported outcomes of salivary function?
Salivary gland dysfunction has multiple causes and can have significant impact on quality of life, particularly when symptoms are severe. There are several patient-reported outcomes (PROMS) that assess these issues; however, these are variable in what they measure. This systematic...
Choosing our tools: assessing language in dementia
Language led dementia, also known as primary progressive aphasia (PPA), is an emerging area of practice in speech and language therapy. Given that the diagnosis centres around the key diagnostic feature of language, whereby language impairment is the most prominent...
