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The structure and function of DNA

DNA structure and replication Genetic information within multicellular organisms, including man, is stored in molecules of deoxyribonucleic acid (DNA), which reside within the chromosomes of each cell nucleus. A DNA molecule consists of two very long chains, or strands, of...

An update on laryngeal reinnervation

Laryngeal paralysis remains very difficult to treat, but reinnervation offers many attractions. Laryngeal paralysis presents a unique and varied problem that requires a patient centred approach and a range of treatment options depending on laryngeal and patient factors. There is...

Clival chordoma recurrence

Chordomas are generally slow growing and are histologically considered low grade tumours. Their high recurrence rate even after postoperative radiation renders them difficult to treat. This is particularly true for clival chordomas whose deep anatomic location and proximity to vital...

Surgical technology and operating room safety failures: lessons from vascular and general surgery

Background – surgical technology and otolaryngology An estimated 234 million major surgical procedures are performed annually worldwide. This requires the interaction of multidisciplinary teams with varying contributions of surgical technology and therefore makes surgical procedures prone to multiple sources of...

From the editor NovDec 2021

It is such a pleasure to see ever-increasing numbers of meetings going ahead in the coming months – after so much time away from physical gatherings, there seems to be a real hunger for in-person conferences where we can meet up with friends and colleagues.

Comprehensive Management of Skull Base Tumors – Second Edition

This is the second edition of a multi-author textbook first published over a decade ago. Most of the chapter authors are North American, as are the editors themselves. There is also a smattering of well-known contributors from the rest of...

The process of medical innovation

You’ve got an amazing idea for a new device. It is going to change how your speciality of surgery is practised. It will lead to better operative results and lower risks to patients – that’s amazing, can I see it?...

Put the maxilla in the right place

This is a paper from Singapore where they attempted to validate the position of the maxilla in the sagittal plane against several reference lines arising from the position of the forehead in orthognathic surgery. The position of the maxilla was...

Monstrous craws and horrid butchery: a concise history of thyroid surgery

Prior to the foundation of our speciality, thyroid surgery had a dubious reputation and universally dismal outcomes. Jenny Walton casts a critical eye over this dark chapter. Diseases of the thyroid gland have been referenced in historic texts for well...

Facing changes after surgery through portraiture

‘Facing Out: Life After Treatment for Facial Cancer’ was a two-year arts-for-health project funded by Arts Council England and The National Lottery which culminated in an exhibition at The Whitworth Art Gallery, Manchester, in February 2019. Here, artist and project...

Selecting and optimising hearing aids for tinnitus benefit: a rough guide

Hearing aids have a relatively long history as tinnitus treatment tools. Saltzman and Ersner reported success in suppressing tinnitus with simple hearing aids in a number of cases as early as 1947 [1]. In an early comprehensive approach to tinnitus...

Plasticity with cochlear implants: individual factors in the outcomes

Andrej Kral gives us an overview of neuronal plasticity in congenital hearing loss, and discusses why it is core to our clinical interventions in hearing loss and rehabilitation. The brain is born immature and undergoes extensive shaping during early development....