You searched for "rhinosinusitis"
Effects on the nasal cavity and maxillary sinus after a Le Fort I osteotomy
This paper from Turkey divided 28 patients into three groups: those having a maxillary advancement osteotomy, those with a maxillary advancement and impaction, and those that underwent advancement with a yaw rotation. They found that pure advancement movement of the...
Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody
Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...
Can we avoid FESS in patients with true isolated odontogenic sinusitis?
This is a useful study looking at how best to manage patients with odontogenic sinusitis and if FESS can be safely avoided. The authors treated patients by removing the odontogenic cause of the rhinosinusitis by extracting the offending tooth and...
How much does CRS affect Eustachian tube dysfunction symptoms?
We know that chronic rhinosinusitis (CRS) and Eustachian tube dysfunction (ETD) are both very common, and that the two often co-exist but this paper looks to establish the prevalence and severity of ETD in CRS patients, and how much treatment...
How to manage the concha bullosa in FESS
It is an interesting concept to assess how much impact the presence of a large concha bullosa (CB) has on both severity of chronic rhinosinusitis (CRS) and also postoperative outcomes after FESS. The authors accept that the paper has limitations...
CRSwNP initiation, not always an interleukin fault
CRSwNP, similar to asthma, is an inflammatory disorder (type II) with eosinophilia and raised IL-5 and IL-13. Inflammation in CRSwNP is thought to be started by IL-25, IL-33 and thymic stromal lymphopoietin (TSLP), all of which form an important part...
IL-25 and nasal polyps, another target
Immune response in chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly via type 2 T-helper (Th2) cells while Th1 cells characterise chronic rhinosinusitis without nasal polyps (CRSsNP) immune response. CRSwNP is heterogeneous on a cytological level causing a varied response...
Removing nasal polyps assists with sleep
This small Scandinavian study looked at sleep quality in patients with CRS and nasal polyposis and whether this is improved by surgery, rated by questionnaires. A cohort of 42 Swedish patients in 2013-14 filled out four different validated sleep and...
Surgery or medicine: when should we stop trying to be conservative?
Although most otolaryngologists would agree that surgery improves the outcomes of patients with CRS when medical treatment has failed, both Cochrane reviews state that there is no proof of improved efficacy of surgery over medicine – however, that was after...
Long-term results for dupilumab are very promising!
Eosinophilic chronic rhinosinusitis (eCRS) is complicated by frequent early and aggressive recurrence of polyps after both medical and surgical treatment regimes. Dupilumab is an anti-IL-4/IL-3 receptor monoclonal antibody and has been previously studied in the SINUS-52 study, with an observation...
Is GERD linked to CRS?
We are all well aware that both chronic rhinosinusitis and reflux are prevalent in our populations. This meta-analysis looked at 25 studies investigating the association between GERD, LPR and CRS, therefore evaluating more than 117,000 patients. The results are fascinating...
