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Interleukins, cilia and polyps
Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...
Painful temporomandibular joints
This paper is a meta-analysis of randomised controlled trials comparing arthrocentesis with conservative management in painful and restricted mouth opening temporomandibular joint symptoms. Temporomandibular joint dysfunction comprises a spectrum of disorders commonly involving facial pain and loss of oral function...
IL-25 and nasal polyps, another target
Immune response in chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly via type 2 T-helper (Th2) cells while Th1 cells characterise chronic rhinosinusitis without nasal polyps (CRSsNP) immune response. CRSwNP is heterogeneous on a cytological level causing a varied response...
Bile acids and pharyngeal malignancy
Laryngopharyngeal reflux is a commonly described condition. There is strong evidence linking gastro-oesophageal reflux with oesophageal carcinomas. Gastric refluxate consists of gastric acid, pepsin and bile acids. The roles of pepsin and acidic conditions in the development of laryngopharyngeal carcinoma...
Tongue twisters to evaluate speech disorders
This interesting study compared errors in tongue twisters produced by adult patients with dysarthria with those produced by age-matched healthy controls. Audio recordings of all patients while they were vocalising tongue twisters were studied. The authors marked one word prominently...
Scoring system to predict hearing impairment following hemifacial spasm surgical treatment
The authors analysed brain stem auditory evoked potentials prospectively in 100 patients undergoing endoscopic microvascular decompression for management of hemifacial spasm over a period of two years. They then developed a scoring system based on electrophysiological events to predict the...
Application of balloon dilatation in chronic eustachian tube dysfunction
Chronic eustachian tube dysfunction prevails in 1% of the adult population and can predispose to middle ear disease. There are subjective and objective features of this condition that can affect quality of life. The common methods to treat eustachian tube...
Occurrence of cancer in asymmetrical tonsillar enlargement in adults
With significant increase in head and neck cancer in the last decade, attributed to HPV, fast-track referrals from primary care have markedly increased, adding further to the burden on the NHS. Whether or not unilateral tonsillar enlargement alone, without red...
Epley Manoeuvre: number of times it is required and its diagnostic value
Benign paroxysmal positional vertigo is a common condition but if inadequately treated or wrongly diagnosed, can prolong the distressing symptoms of momentary dizziness, nausea and visual disturbances which can be due to other causes and deteriorate quality of life. Studies...
Best timing for post-treatment PET-CT scans in head and neck cancer
Unfortunately we know that the recurrence rate for head and neck cancer can be high, up to 30-50% in some series. These recurrences tend to occur within the first two years following treatment. Optimal surveillance strategies to detect recurrences early...
Leisure listening does not affect the hearing of young people
The existing literature highlights concerns regarding the possibility of leisure activities involving listening to music on portable music players causing hearing loss. However, there is much speculation regarding actual effect. This article outlines a project involving young persons aged between...
