You searched for "molecular"

274 results found

Antioxidants for bacterial rhinosinusitis

This Turkish laboratory animal-based study looked at the effects of alpha-lipoic acid on inflammation, oxidative status, and tissue integrity in an animal model of experimentally induced acute rhinosinusitis and to compare these effects with antibiotic treatment using cephalosporins. Alpha-lipoic acid...

NASBS (North American Skull Base Society) 29th Annual Meeting

Report By: Gauri Mankekar, OLOL Hearing and Balance Center, Baton Rouge, Louisiana, USA The 29th Annual North American Skull Base Society (NASBS) Meeting was organised by President James Evans with co-chairs, Amir Dehdashti and Adam Zanation. Delegates consisted of neurosurgeons,...

Head and neck robotic surgery – considerations for the surgical trainee

In 2021, training in head and neck cancer surgery would be incomplete without some robotic resections under the belt. Henry Zhang explains how he did it and outlines the options available. With a wide range of applications in both benign...

Cancer genetics and signalling pathways in ENT – a review and discussion of how this can be applied to rare tumours

Introduction Cancer cases continue to increase worldwide, and­­ head and neck cancer is a major global health issue, with an estimated global burden of over 630,000 new cases and over 350,000 deaths per year [1]. The term ‘head and neck...

The future of head and neck cancer surgery

Neil Sharma paints an exciting picture of the future of head and neck surgery with nanobots and robot augmented humans – science fiction or reality? Time will tell. ‘May you live in interesting times’ reads the old Chinese curse. The...

COOL therapy for cisplatin-induced hearing loss

Cisplatin is a commonly used cancer therapy, with nearly 50% of patients undergoing chemotherapy receiving cisplatin as part of their regimen [1]. Depending on the dose, incidence of hearing loss has been reported as 12-100% in adults, and 37-94% in...

The future of biologics?

This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...

Lancet Commission on Hearing Loss

The Lancet Commission on Hearing Loss was convened in 2019, and its main report will be published in 2023. We learn more about it here. The Lancet Commission on Hearing Loss was convened in 2019, and was charged by Richard...

Role of fine needle aspiration cytology in the management of thyroid neoplasm

Fine needle aspiration cytology (FNAC) is a useful procedure in the assessment of thyroid swellings. This retrospective study was done at King Abdul-Aziz University hospital, King Saud University, Riyadh. The objectives of this study were: to determine the cytological pattern...

Role of potassium channel opener in salicylate induced tinnitus

The exact mechanism in the origin of tinnitus is not known. Many pharmacological agents have been tried to to treat tinnitus without great success. Aspirin is a commonly used medicine in the elderly population to reduce the risk of stroke...

The changing landscape for hearing loss therapeutics: novel advances of gene and cell therapies

Recent years have seen advances in hearing loss therapeutics, with novel treatments trialled in humans, and others nearing promising first-in-kind clinical trials. First successful clinical trials for a specific form of genetic hearing loss Very exciting news has emerged in...

Discovery in the genetics of complex disease: Otitis media

Otitis media (OM), a common disease of childhood, is considered to be a complex trait with multiple genetic and environmental factors expected to contribute to a child’s risk of developing recurrent acute OM (rAOM; ≥3 episodes in 6 months or...