You searched for "Cell"

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The structure and function of DNA

DNA structure and replication Genetic information within multicellular organisms, including man, is stored in molecules of deoxyribonucleic acid (DNA), which reside within the chromosomes of each cell nucleus. A DNA molecule consists of two very long chains, or strands, of...

Head and neck cancer and PET-CT

Positron emission tomography-computed tomography (PET-CT) is an imaging technique in which abnormalities of tissue metabolism are precisely superimposed onto the anatomy. It relies on the premise that malignant cells are more metabolically active compared with non-malignant cells. On this basis,...

Smoking causes cancer – so what’s new?

You may well ask what is the novel value of a paper looking at smoking habits in patients with confirmed head and neck squamous cell carcinoma (HNSCC), but this paper highlights some pertinent points for clinical practice in the current...

Prestigious Global Engineering Medals Awarded to Cochlear Implant Inventors Ingeborg and Erwin Hochmair

Austrian cochlear implant pioneers, Dr Ingeborg Hochmair and Prof Erwin Hochmair have been granted the 2023 IEEE Alexander Graham Bell Medal for their outstanding contribution to communication and engineering.

Chronic rhinosinusitis management: back to the future?

Immunology is a dim and distant medical school memory to many ENT surgeons, but the increasingly complex immunology of chronic rhinosinusitis is fascinating (honestly!). Medical management options in CRS no longer just involves saline and steroids, and we need to...

Lymph node ratio in tongue cancer

This is an analysis of 88 patients treated in Switzerland between 2003 and 2012. All patients had a selective neck dissection and recurrence occurred in 25 patients. Overall and disease specific survival were 72% and 80%. They specifically looked at...

Novel method for determining BCC margins

This correspondence describes a new technique for determining basal cell carcinoma (BCC) borders, to aid in obtaining clear peripheral resection margins. Whilst this can be straightforward in small well-defined nodular BCCs, some BCC subtypes are ill-defined or morphoeic, and resection...

Risk of second primary cancer among patients with head and neck cancers

Patients with head and neck squamous cell carcinoma (HNSCC) have an elevated risk of developing a second primary malignant neoplasm (SPMN). These are of increasing concern because the number of survivors of HNSCC has been growing owing to early detection...

Retrospective review of paediatric salivary gland tumours

As is the case with adults, primary tumours of the salivary glands in children comprise a heterogeneous collection of different histological types. This paper presents a retrospective review of primary salivary gland tumours in children treated over the course of...

Intermediate risk factors SCC tongue

This retrospective review from Japan assessed 89 patients who underwent surgery for squamous cell carcinoma of the tongue, specifically they reviewed the evidence of perineural and vascular invasion (27.0% and 23.6%). Their results suggest, not unsurprisingly, that perineural and vascular...

No difference upper or lower lip

This is a retrospective review from the Netherlands over a 20-year period to 2009 of squamous cell carcinoma (SCC) of the lip. In total, 979 cases of the lower lip were identified and 126 of the upper lip, with men...

When ears go bad

Whilst rare, squamous cell carcinoma is the commonest primary malignancy of the temporal bone and is discussed in this review article. This tumour frequently presents with otalgia, ottorhoea and hearing loss; less commonly, with facial palsy or parotid mass. Investigations...