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A drug to prevent hearing loss caused by ototoxic therapeutics

This editorial briefly highlights the progress made in discovering a compound named ORC-13661, which shows the potential to alter the response of hair cells to ototoxic medication. In the late 1980s, inner hair cells that were lost secondary to noise...

Performing ethnic aesthetic rhinoplasty

This article reviews principles of performing rhinoplasty in non-Caucasian patients, exploring patient expectations based on differences in race, ethnicity and culture. One of the main challenges is a lack of well-established ideal facial measurements for different non-Caucasian groups. The authors...

Prevention better than cure?

This systematic review looks at methods of ‘barrier protection’ or ‘barrier-enforcing’ to minimise allergic rhinitis symptoms, using 15 RCTs. Whilst the authors admit that patient numbers were small in a number of these studies, generally it seems that barrier techniques...

Talking it through: voice therapy

The authors begin this article by highlighting two issues in voice therapy: 1. the high rate of relapse and 2. poor attendance at appointments. They attribute this to there not being carryover (or generalisation) work embedded into most voice therapy...

Nasal deformity following CPAP injury

Nasal continuous positive airway pressure (nCPAP) is commonly used as a non-invasive alternative to endotracheal intubation and tracheotomy to provide respiratory support to very low birth weight (VLBW) (<1500 g) neonates. Nasal injury is a well recognised complication and figures...

Audiology Treatment

This book brings a great new comprehensive text to audiologists. It is readable, despite most chapters being written by different authors. Dr Galster has edited a collection of chapters from experts in their field into something that is comprehensive, totally...

Diagnosis and management of acute sensorineural hearing loss: a Japanese perspective

In this paper, the authors set out the clinical guidelines to standardise diagnosis and treatment of acute sensorineural hearing loss in Japan. They categorised acute sensorineural hearing loss into five disorders: idiopathic sudden sensorineural hearing loss (iSSNHL), acute low-tone sensorineural...

Allergic rhinitis, the usual suspects

Allergic rhinitis (AR) is characterised by allergen binding to IgE on mast cells and basophils and subsequent histamine, prostaglandine D2 (PGD2) and cysteinyl leukotrienes (cysLTs) release causing early-phase response. This is followed by late-phase response mediated by eosinophils. Other cells,...

Precision medicine in allergic rhinitis and chronic rhinosinusitis

Precision medicine (PM) with its ‘four Ps’ (personalised, predictive, preventive and participatory) is about appreciating differences between individuals when offering management options for health problems. Multiple groups interested in rhinology such as EPOS and ARIA supported a review of the...

Can a serpent-shaped graft enhance your nose?

The success of rhinoplasty is highly variable and the technique employed by the operating surgeon must be tailored for different patient demographics. This group from China describes the structural differences in nasal configuration within the Asian population, notably an under-projected...