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Interleukins, cilia and polyps
Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...
Molecular and genetic nature of skull base tumours drives management
This article reviews the molecular basis and paradigm shift in the diagnosis and management of skull base tumours. It is now known that the phenotype of meningiomas is influenced by their genotype. Endolymphatic sac tumours are observed in up to...
Factors affecting the occurrence of salivary fistula after total laryngectomy
It is generally believed that patients should be fed by nasogastric tube for 7-10 days after undergoing total laryngectomy or laryngopharyngectomy to avoid the occurrence of post-operative salivary fistula. This study challenges this belief and looks into various factors that...Obituary: John Noel Gleave Evans (1934-2022)
John Noel Gleave Evans DLO FRCS, formerly consultant otolaryngologist to St Thomas’ Hospital and Great Ormond Street Hospital for Children, died peacefully at home on 27 March 2022 at the age of 87.‘Bare below the elbows’
So it has finally happened. I have reached that stage of reactionary bewilderment known as middle age. As well having my finger nowhere near the pulse of contemporary culture, I am finding the siren charms of BBC Radio 2 and...
Two for the price of one - multiple parotid neoplasms
With advancing years come many benefits, but one drawback is the acquisition of parotid (or thyroid) neoplasms. Conventional teaching is that most are benign and slowly enlarge, and not infrequently are found bilaterally as in Warthin’s. Pleomorphic adenomas are also...
Pituitary tumour associated headaches
This longitudinal cohort study presents data with significant clinical implications for patients with headaches and the clinicians and surgeons who treat them. For the study, patients completed a self-administered survey on headache characteristics on initial presentation and after surgery of...Thoughts on war: von Clausewitz revisited
We few, we happy few, we band of brothers; For he to-day that sheds his blood with me Shall be my brother; be he ne’er so vile, This day shall gentle his condition: And gentlemen in England now a-bed Shall...Hearing ‘aid’ for Ukraine
Hearing Aid Recycling (HAR) has partnered with Ukraine’s Vidchui organisation to deliver 1000 hearing aids to those affected by war. This collaboration provides essential support for military personnel and civilians suffering from hearing loss, highlighting the power of global solidarity...
New biomarkers for salivary gland tumours
Salivary gland tumours comprise approximately 6-8% of head and neck neoplasms. Elevated haematological inflammatory markers, such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), have been shown to be predictive and prognostic in various malignancies. This...
