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Immunosuppresants and ototoxicity
There is a wide range of immunosuppressant drugs ranging from calcineurin inhibitors (e.g. cyclosporine), anti-folic agents (e.g. methotrexate) to anti-TNF and monoclonal antibodies, many of which could be ototoxic. The authors performed a systematic review assessing ototoxicity secondary to immunosuppressant...
Is there an association with cognitive impairment and hearing loss in a developing country?
Hearing loss (HL) is the third leading chronic health condition among older adults. Most studies investigating HL and cognition have been performed in high-income countries. Risk factors for dementia (eg. hypertension, midlife hearing loss, obesity and physical inactivity) are more...
Can prediction models help identify dysphagia in ventilated patients?
Dysphagia commonly affects patients in intensive care units (ICU), particularly those on mechanical ventilation, and is associated with high risk of mortality. This systematic review and meta-analysis aimed to identify predictors for dysphagia in ventilated ICU patients by summarising existing...
Reducing pulse rate in videofluoroscopy: less is not best!
Recently, there has been increasing discussion in clinical meetings about the use of ionising radiation in swallowing assessments and the associated cancer risks. This is therefore a timely publication to inform discussions around whether reducing pulse rate from 30 pulses...
Measuring radiation fibrosis in patients with head and neck cancer
People treated with radiotherapy for head and neck cancer experience several acute and chronic effects of this treatment, of which fibrosis is perhaps the most common. Fibrosis occurs as a wound healing response and leads to scarring and reduced range...
Cognitive development in children with cochlear implants
This systematic review investigates the comparative cognitive outcomes in children using bilateral versus unilateral cochlear implants, as well as those using cochlear implants versus hearing aids. The review synthesises findings from 30 studies involving a total of 11,986 children and...
Eosinophilic complications during dupilumab therapy
Dupilumab is a humanised monoclonal antibody that targets type 2 inflammation by blocking IL-4 and IL-13 signalling. Reported adverse events from its use include injection site erythema, conjunctivitis, arthralgia and hypereosinophilia. The potential for more severe eosinophilic-related complications such as...A surgeon’s perspective on the challenges facing cochlear implantation in children
Cochlear implantation in children offers a different set of challenges and goals to adult practice. In this article, Iain Bruce, Professor of Paediatric Otolaryngology in Manchester, UK, explains some of the current clinical and research challenges in paediatric cochlear implantation,...Trainee-led collaborative research and audit in ENT: where are we now?
In late 2015 INTEGRATE, the UK ENT Trainee Research Network, was formed. Since then, two national projects have been completed and INTEGRATE has grown into a larger, more structured organisation, with otology, head and neck and rhinology subcommittees working alongside...Intratympanic treatments for subjective idiopathic tinnitus
Direct application of medication into the ear is long established, going back as far as written records. In the modern era, greater understanding of aural anatomy revealed that drugs instilled in the middle ear could potentially diffuse into the cochlea...
Time and Life Management for Medical Students and Residents
Time and life management is not normally a skill we are taught growing up. As we grow from being a child to an adult, it is inevitable that we become independent managers of our time and schedule. Most who end...
