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In conversation with Emma Stapleton, winner of the Hunter Doig Medal 2022
The Hunter Doig Medal is awarded once every two years to a female Fellow or Member of the Royal College of the Surgeons of Edinburgh who has demonstrated outstanding career potential and ambition. The medal is named after two female surgeons, Alice Headwards-Hunter and Caroline Doig.Biologic therapies for chronic rhinosinusitis with nasal polyps: a new paradigm
Surgery for nasal polyposis has evolved significantly in the last 30 years, and now the medical management may be on the cusp of a revolution. Biologics using monoclonal antibodies to target specific immune pathways have introduced a paradigm shift in...
Chronic phase of concussion and stability of gaze
It has been known that vestibular symptoms can persist for several months after concussion. The authors designed this study to assess the effect of chronic concussion (more than one year) on gaze stability and the relationship between deficits in gaze...
CRSwNP, another monoclonal antibody
Interleukins 4, 5 and 13 were shown to be important factors in type 2 inflammation, which characterises chronic rhinosinusitis with nasal polyposis (CRSwNP). In CRSwNP non-responders and those who recur short after-surgery monoclonal antibodies might be an answer. Examples include...
The effect of cocaine or adrenaline dressing during endoscopic sinus surgery
A randomised controlled study of 37 patients took place that underwent endoscopic sinus surgery for chronic rhinosinusitis and received adrenaline or cocaine-soaked patties. The study showed no difference in the mean surgical field scores between adrenaline and cocaine sides. Adequate...
Do we need to intervene after complications of acute sinusitis in children?
omplications of acute sinusitis in children are not uncommon and some are managed surgically. The authors of this paper reviewed their experience of subsequent chronic rhinosinusitis (CRS). Nine of 86 patients required surgery in the 12 months after their initial...
Is there increased cardiovascular risk with macrolide antibiotics?
This month’s Ed’s Choice delightfully reviews the potential cardiovascular consequences of long-term macrolide use in the treatment of chronic rhinosinusitis. This used to be one of my ‘go-to’ topics of conversation at home after a bad day at work, although...
Fungal rhinosinusitis
Allergic fungal rhinosinusitis (AFRS) has been defined by the following characteristics: presence of nasal discharge, nasal obstruction, decreased sense of smell or facial pressure for 12 weeks, mucin within the sinus cavity containing fungal hyphae and degranulating eosinophils, endoscopic evidence...
Biologicals for severe chronic rhinosinusitis with nasal polyps. Any use?
Recent advances and knowledge of inflammatory endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) led to introduction of biological agents such as monoclonal antibodies targeting IgE (omalizumab) and Interleukins (ILs) such as IL4R alpha (dupilumab) and IL5. The European Academy...
Nasal polyps, does size matter?
This study from Germany investigates the correlation between nasal polyp size and return of olfactory function following endoscopic sinus surgery. Olfaction is affected more in patients with CRSwNP than with CRSsNP and the best chance of smell recovery occurs in...
Does endoscopic sinus surgery for chronic rhinosinusitis improve COPD?
Chronic rhinosinusitis (CRS) can be associated with asthma, with a reported frequency of asthma in patients with CRS of up to 44%. COPD is another lung condition that can be associated with CRS. This longitudinal study reviewed the nasal and...
