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Precision and personalised genomic and epigenomic medicine in audiology/hearing loss
A detailed look at the pathogenesis of acquired hearing loss due to exposure to ototoxicity during pregnancy or shortly after birth. Insights from genomic medicine have shown that, along with environmental factors causing epigenetic alterations, hearing loss may be caused...
Facial nerve grafting – what’s the wait?
An uninterrupted facial nerve after resection of cerebellopontine angle (CPA) tumour does not always translate into preserved facial animation. Fortunately there is a high probability spontaneous recovery may occur and hence patients are typically observed for 12 months postoperatively. However,...
Cochlear implantation in children with congenital long QT syndrome
Jervell and Lange-Neilsen syndrome is a condition where sensorineural deafness coincides with inherited abnormalities of the heart, resulting in prolonged ventricular repolarisation, frequently shown on an ECG with a prolonged QT interval. These children can present at implant centres for...Living with Usher syndrome
“Usher people often still have sharp, clear central vision. It is the corner of their eye that is missing. This is why the Usher person often does not feel or look blind. In the early days they may not even...
Association of diabetes mellitus type 2 with age-related changes in the larynx
Diabetes affects the body with changes in the neurological, muscular and vascular systems. It is therefore conceivable that the larynx, which is a musculoskeletal organ, can be adversely affected by type 2 diabetes mellitus. To explore this possibility, 174 Caucasian...
REVISIONS acronym for preoperative imaging review in revision endoscopic sinus surgery
The authors have developed an acronym to aid evaluation of preoperative sinus CT imaging in revision endoscopic sinus surgery (RESS). To determine which pertinent aspects of anatomy to include, a systemic review of studies that investigated anatomic contributions to persistent...The search for pharmacological treatments for hearing loss and tinnitus
Where are we in our search for a hearing restoration grail? Nicola Robas leads us through the map pieces discovered in creating a pharmaceutical answer to hearing loss and tinnitus. Together, hearing loss and tinnitus affect over one in six...
Vestibular functions of hereditary hearing loss patients with GJB2 mutations
Mutations of the GJB2 gene are a common cause of deafness, being found in 15-25% of cases of congenital deafness. Over 100 mutations are now recognised and may be associated with a hearing loss ranging from mild to profound. This...
Cochlear Implants - Audiologic Management and Considerations for Implantable Hearing Devices
This book aims to serve as a must-have resource for those in higher education in audiology and cochlear implant audiologists wanting to go the extra mile in their approach to maximise clinical outcomes for their patients. Jace Wolfe is a...
