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COVID-19 in patients with chronic rhinosinusitis with polyps. Are they at risk?
COVID-19 entry factors are highly present in nasal epithelial cells. These factors include ACE2 and TMPRSS2. Their presence in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) was not investigated before. Authors investigated expression of ACE2 and TMPRSS2 in two...
Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody
Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...
Till death do us part: the role of the speech and language therapists in palliative care
Increasingly, speech and language therapists are being involved in end-of-life and palliative care. This study reports on a three-phase project to explore this in the context of the Australian healthcare system. In phase one, the authors described a scoping review...
An objective office-based method for diagnosing allergic rhinitis
There are several signs of allergic rhinitis which, helped with skin prick and blood tests, can diagnose the problem. However, an endoscopic, on-the-spot test may surmount clinical uncertainties and invasive testing to acquire the same goal. In this study, the...
Two reliable endoscopic myringoplasty techniques for anterior tympanic membrane perforations
Difficulties that arise in closing anterior perforations in the tympanic membrane are due to a narrow isthmus of the external auditory canal and an anterior wall bulge which obscures the most anterior part of the tympanic membrane. The conventional microscopic...
What is the right balance to strike in the management of anaplastic thyroid cancer?
This is a pragmatic article on a difficult and much debated subject. Management of anaplastic thyroid cancer (ATC) can feel like making decisions between a rock and a hard place, and this article suggests one path to help navigate some...
Possible correlation of ABR changes with prognosis in sudden sensorineural hearing loss
A sensorineural hearing loss (SNHL) of 30dB or more affecting at least three frequencies and occurring over less than three days is classified as ‘sudden’ SNHL (SSNHL). Treatment is urgently undertaken with systemic and/or intra-tympanic steroids, and ijn some cases...
Endoscopic stapes surgery
This retrospective Turkish study looked at the audiological and surgical outcomes of 40 patients who underwent endoscopic stapes surgery over a three-year period. To assess the learning curve, the patients were divided into two groups based on the date of...
Hierarchy of orthognathic surgical stability
This study was designed as “an overview” of secondary studies and analysed 15 articles. Two procedures were considered highly unstable: a bilateral sagittal split osteotomy for clockwise rotation of the mandible with bi-cortical screw rigid internal fixation, and posterior maxillary...
Bright young things: executive functioning in younger, older and aphasic people
Executive function comprises several higher order cognitive processes such as planning, organisation, adaptation, maintenance, monitoring and decision making. It is thought that difficulties in cognitive flexibility in people with aphasia are associated with difficulties in executive function rather than the...
Choline PET-CT: an accurate diagnostic tool for the detection of parathyroid adenoma?
Hyperparathyroidism (HPT) is an endocrine disorder characterised by an increase in the secretion of parathyroid hormone (PTH), with a resulting increase in calcium plasma levels, which can cause renal lithiasis, fractures, and osteoporosis, the most frequent symptoms of the disease....
