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A drug to prevent hearing loss caused by ototoxic therapeutics
This editorial briefly highlights the progress made in discovering a compound named ORC-13661, which shows the potential to alter the response of hair cells to ototoxic medication. In the late 1980s, inner hair cells that were lost secondary to noise...
Hypopharyngeal Cancer
The 83rd book from the series by Advances in Oto-Rhino-Laryngology is another addition for the surgeon looking for an update in the management of hypopharyngeal carcinoma. The 180-page publication, divided into 16 chapters with 23 figures and 19 tables, has...Singing after laryngectomy: Shout at Cancer
Thomas Moors is an ENT junior doctor with a background in music and singing. Combining these interests, he has set up a charity to help patients who have had a laryngectomy. He has achieved considerable public attention, and he tells...Chronic cough hypersensitivity syndrome
We all have patients who give us a ‘heartsink’ feeling; for many of us, the coughing patient is exactly such a situation. In this overview, Bhaskar Ram and Sangeeta Maini outline their approach to diagnosis. Declan Costello, Editor. Introduction Chronic...Entrepreneurial aspirations for the otolaryngologist
Entrepreneurship is a process of identifying an idea and starting a business venture with this idea. It requires generation of a business model or plan that emphasises the value proposition for the customer. The model must identify the partners, resources,...
Paediatric hearing following chemotherapy
This study examined the effect of platinum compounds on hearing in 104 children with solid tumours. As would be expected, this group was heterogeneous and included a range of ages, tumour types, chemotherapeutic agents and dosing regimens. Age-appropriate audiometry was...
Laryngeal oedema as a side-effect of tyrosine kinase inhibitor therapy
Tyrosine kinase inhibitors (TKIs) such as Imatinib are increasingly being used to treat haematological and solid malignancies. These agents have revolutionised the treatment of chronic myeloid leukaemia in particular. Although better tolerated than most conventional chemotherapy drugs, multiple side-effects have...
The evidence for various treatments of autoimmune ear disease
The difficulty with this disease entity is that it is a heterogeneous group of conditions affecting the ear and a widely accepted diagnostic criteria does not exist. It is therefore difficult to conduct a well controlled trial and this systematic...
