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Aspirin desensitisation for aspirin-exacerbated respiratory disease (AERD)
In this article, the authors describe the importance of identifying aspirin-exacerbated respiratory disease in patients with chronic rhinosinusitis refractory to standard medical treatment. This can then open the door to considering aspirin desensitisation treatment which, in their hands, has proven...
Video- Based Aural Rehabilitation Guide
This book provides thorough coverage of vital topics within aural rehabilitation for children and adults. It targets a wide audience, including audiologists, speech therapists, Teachers of the Deaf and parents. It can also be used by clinicians supporting people with...Staphylococcus aureus as a cause of refractory chronic rhinosinusitis
Staphylococcus aureus has long been linked to chronic rhinosinusitis, particularly recalcitrant cases. In this article, Alkis Psaltis describes how newer techniques have shown higher rates of S. aureus infection than were previously thought, and explains how the bacteria are able...
Symptom Oriented Otolaryngology: Head & Neck Surgery – Three Volume Set
Symptom Oriented Otolaryngology is a three-volume set covering an extensive range of symptoms in otorhinolaryngology, head and neck surgery. The editorial team of Randal Morton, Zahoor Ahmad and Malcolm Giles from New Zealand, have been supported by an illustrious team...
Otolaryngology Head and Neck Surgery: Clinical Reference Guide – Sixth Edition
When I began my ENT training, the revered ‘Pasha’ textbook was one of the first recommendations given to me by senior colleagues who were in the throes of FRCS revision. This revamped edition serves to improve a book which was...
Waiting for smell to recover after post-viral hyposmia
The patient with post-viral anosmia will always want to know how long they must wait to reach a plateau. This study from South Korea of a comparatively small group (20 controls and 63 patients) tells us that favourable prognostic indicators...
An advance in imaging for sinonasal tumours?
Benign sinonasal growths are incredibly common, and malignant sinonasal growths thankfully rare. We know that malignant tumours often present late, and the imaging can sometimes be misleading, so the authors here compare using diffusion weighted imaging (DWI), dynamic contrast enhanced...
Does pollution worsen inflammatory nasal problems?
This ambitious study, conducted over a period of four years, assessed 27,863 patients and compared levels of allergic rhinitis (AR) or chronic rhinosinusitis (CRS) with the levels of air pollution recorded, as assessed by levels of particulate matter (PM10). They...
The polyp shrinker
Inflammatory markers, including T2 cells beta common (βc) cytokines IL-3, IL5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), are known to play an important role in chronic rhinosinusitis with nasal polyps (CRSwNP). CSL311, a monoclonal antibody (mAb), was developed to target human...
Allergic rhinitis, the usual suspects
Allergic rhinitis (AR) is characterised by allergen binding to IgE on mast cells and basophils and subsequent histamine, prostaglandine D2 (PGD2) and cysteinyl leukotrienes (cysLTs) release causing early-phase response. This is followed by late-phase response mediated by eosinophils. Other cells,...
The hippo and the nose
Chronic rhinosinusitis with nasal polyps (CRSwNP) leads to histological changes including thickening of the basilar membrane and epithelial proliferation. Molecular mechanisms underlying these changes are still not fully clear. A signalling pathway called the hippo with Yes‐associated protein (YAP) as...
