You searched for "inflammatory"
Antioxidants for bacterial rhinosinusitis
This Turkish laboratory animal-based study looked at the effects of alpha-lipoic acid on inflammation, oxidative status, and tissue integrity in an animal model of experimentally induced acute rhinosinusitis and to compare these effects with antibiotic treatment using cephalosporins. Alpha-lipoic acid...The common frontal sinusotomy (Lothrop) and chronic rhinosinusitis
As our understanding of the pathophysiology of CRS evolves, so do our treatment strategies. It is accepted that in many cases, the main role of surgery is to allow better penetration of topical therapies to the sinus cavities. What, then,...
Interleukins, cilia and polyps
Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...
CRSwNP, another monoclonal antibody
Interleukins 4, 5 and 13 were shown to be important factors in type 2 inflammation, which characterises chronic rhinosinusitis with nasal polyposis (CRSwNP). In CRSwNP non-responders and those who recur short after-surgery monoclonal antibodies might be an answer. Examples include...
Leptin has no role in idiopathic sudden sensorineural hearing loss
This paper from Turkey claims to be the first study dealing with the relationship between leptin and idiopathic sudden sensorineural hearing loss (ISSHL). I remember leptin being a fashionable topic in obesity research, when leptin deficiency was thought to be...
Systemic steroid therapy for reduction of macrophage migration inhibition factor in the control of nasal polyposis
It is believed that macrophage migration inhibitory factor mediates inflammation by stimulating the release of other pro-inflammatory cytokines. The use of systemic steroids in control of nasal polyposis is an established treatment. In this study the authors have aimed at...
A new biomarker for chronic rhinosinusitis
This Chinese study looked at the feasibility of periostin (usually found in bone and lung tissue) as a biomarker for chronic rhinosinusitis. They sampled ethmoid mucosa in 12 patients with chronic rhinosinusitis without nasal polyposis (CRSsNP) and 25 patients with...
Role of intranasal steroids after radiotherapy for nasopharyngeal carcinoma
Rhinosinusitis often follows radiotherapy in the treatment of carcinoma of the nasopharynx. The interval and severity may vary with the dose of radiation and stage of the carcinoma. In this randomised, controlled study, patients who developed rhinosinusitis after radiotherapy treatment...
Allergic rhinitis, the usual suspects
Allergic rhinitis (AR) is characterised by allergen binding to IgE on mast cells and basophils and subsequent histamine, prostaglandine D2 (PGD2) and cysteinyl leukotrienes (cysLTs) release causing early-phase response. This is followed by late-phase response mediated by eosinophils. Other cells,...
Zinc and rhinosinusitis
Patients with chronic rhinosinusitis (CRS) in general, and those with nasal polyps (CRSwNP) in particular, have been shown to have down-regulation of tight junction genes. Zinc, on the other hand, is well-known for its role in immune regulation and deficiency...
Influence of smoking on vocal fold polyps
A vocal fold polyp is a benign lesion related to phonotrauma which induces upregulation of inflammatory processes and histological changes can occur in the epithelium and lamina propria. Whether smoking produces additional or enhanced changes is the subject of this...
