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What should be considered a ‘close’ margin in oral cavity squamous cell carcinoma?
Achieving clear margins during surgical resection in oral cavity squamous cell carcinoma (OCSCC) is thought to reduce local recurrence (LR) and improve prognosis; however, what constitutes a clear, close, or involved margin is inconsistent in the literature and in practice....
Evidence for diagnostic role of narrow band imaging in the outpatient setting for head and neck squamous cell carcinoma
Narrow band imaging (NBI) uses light in the blue and green spectrum to differentiate areas of carcinoma from normal or inflammatory tissue. This tertiary referral head and neck unit in Spain used white light endoscopy as initial screening for all...
Active smoking predicts poor outcome in HPV positive oropharyngeal squamous cell carcinoma
Tobacco smoking is a well-known risk factor in human papilloma virus (HPV)-negative head and neck squamous cell cancer. Its effects include increased risk of treatment failure, distant metastases and reduced overall survival. HPV has been increasingly implicated as a causative...Allergy – what’s in a name?
Allergy is defined as an “abnormal immune reaction to an ordinarily harmless substance” [1], however the meaning of the word has taken many forms since its introduction in 1906 by Austrian Paediatrician and Immunologist, Clemens von Pirquet [2]. Combining his...
Stem cells in nasal polyposis
Chronic rhinosinusitis with nasal polyps (CRSwNP) is common and is multifactorial with increased T-helper 2 response and active role of interleukin 5. It can be associated with asthma and control of CRSwNP improves lower airway disease. Due to constant cellular...
Blood-sampling prognostic predictors for Bell’s palsy
Bell’s palsy is generally defined as an acute-onset unilateral idiopathic mononeuropathy in the facial nerve. It is of unknown aetiology, however, inflammation is considered a major cause. Electroneurography assessing nerve excitability is the most reliable examination for predicting prognosis of...
Relationship between ART and language development
Assisted Reproduction Technology (ART) and especially more invasive techniques of ART may be associated with an increase in neurodevelopmental problems including language delay. Some studies have reported slightly worse perinatal outcomes of IVF babies compared to naturally conceived babies. The...
Assessing the impact of e-cigarette smoke on the vocal fold
While the use of electronic-cigarettes (e-cigs) is increasing rapidly, little is known about the effects this has on the health of vocal fold. In this translational research study, authors compared the effects of e-cig vapour and cigarette smoke on an...
Role of intratympanic corticosteroid for treatment of Bell’s palsy and Ramsay Hunt syndrome
Acute peripheral facial palsy occurs annually in 30 in 1,000,000 individuals in the general population. Bell’s palsy and Ramsay Hunt syndrome account for about 70% of cases of peripheral facial palsy. They are believed to be caused by viral reactivation...Getting to grips with acoustic trauma
Our understanding of hearing loss caused by noise exposure to those in the armed forces is growing in interest and understanding. Research at a cellular level is essential to increase our understanding so that we can better diagnose, manage and...What’s new in the cochlea?
Prof Furness in this article rounds up the steps and leaps being made by the scientific community to develop therapies to support, rejuvenate and / or replace the cochlear structures. David’s electron microscope images of the cochlear structures are world...
