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Molecular and genetic nature of skull base tumours drives management

This article reviews the molecular basis and paradigm shift in the diagnosis and management of skull base tumours. It is now known that the phenotype of meningiomas is influenced by their genotype. Endolymphatic sac tumours are observed in up to...

The future of biologics?

This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...

Motor learning: better knowing how, not how well

Motor learning is described as the ability to perform a motor skill due to practice and/or experience. Research on interventions to enhance limb motor skills can be influenced through the amount, distribution, variability and schedule of practice as well as...

From patient to performer

Peter Cawrey lives in Harpenden, Hertfordshire, with his wife Dorothy. He had a salvage laryngectomy for squamous cell carcinoma in 2015, three years following his initial radiotherapy. Due to complications and a complex recovery, he has elected not to have...

Bishop Berkeley and the Freireich experimental hypothesis

Our resident reporter at large tells us about two of his heroes, both of whom have quite clear merits and foibles. My patients just keep on getting better. You may well point out that under the care of a clinician...

Clinical leadership and management: the ‘Darzi’ experience

The Fellowship in Clinical Leadership programme, more commonly known as the ‘Darzi Fellowship,’ commenced in 2009. It was designed to provide junior doctors at the registrar level with postgraduate training in clinical leadership and change management in order to develop...

Occlusal splint, injections or arthrocentesis in myofascial pain

Facial pain is a fairly common complaint and may present in a myriad of symptoms. These patients present to both dentists and general practitioners and could end up referred to a number of specialists. Temporomandibular disorders may originate from either...

The basis of auditory processing disorder: what can we learn from corticals?

Auditory processing disorder (APD) is a poorly understood, heterogenous and surprisingly common condition. It manifests as a perceptual difficulty in centrally processing auditory information. Diagnosis is usually based on a variety of behavioural tests involving verbal and non-verbal assessments. In...

Outcomes of office-based biopsies for laryngopharyngeal carcinoma – faster diagnoses and equivalent oncological outcomes as compared to biopsies under general anaesthesia

Patients in the UK with head and neck cancers are the most likely to face long waits to treatment in comparison to other cancer sites, with only just over half commencing treatment within 62 days of being referred on a...

Ramsey Hunt causes more widespread vestibular dysfunction that other causes of acute peripheral vestibulopathy

The extent of semicircular canal dysfunction in different conditions causing acute vestibular syndrome (AS) has not been widely studied. The authors share their findings in a retrospective study of patients presenting with AVS in three conditions: Ramsay Hunt syndrome (RHSD),...

Some guidelines for treating rhinological patients during the COVID-19 pandemic

This is a very interesting and informative multinational European guide to the treatment of rhinology patients during the current pandemic, describing the safe delivery of a rhinological service to patients. Much of this has become well understood and standard practice...

Research funding opportunity for audiologists

A research funding call is encouraging applications from disciplines that rarely lead clinical research, offering an important opportunity for UK audiology. It comes from the Research for Patient Benefit (RfPB) Programme of the National Institute for Health and Care Research (NHCR) and aims to strengthen the careers of under-represented disciplines and specialisms.