You searched for "genomics"

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The polyp shrinker

Inflammatory markers, including T2 cells beta common (βc) cytokines IL-3, IL5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), are known to play an important role in chronic rhinosinusitis with nasal polyps (CRSwNP). CSL311, a monoclonal antibody (mAb), was developed to target human...

Recurrent ENT infections in children – is it a sign of primary immunodeficiency disease?

ENT clinicians often come across children with recurrent ear, sinus and pulmonary infections. These recurrent infections, albeit common in childhood, can represent an early sign of primary immunodeficiency diseases (PIDD). PIDD is an underdiagnosed group of genetic disorders involving absent...

Clinicopathological features of follicular variant of papillary thyroid carcinoma

The follicular variant (FV) of papillary thyroid carcinoma (PTC) is characterised by the presence of nuclear features of PTC together with a follicular growth pattern. It is currently reported to make up 11.8% to 53.3% of all PTC cases. It...

Textbook of Otitis Media: The Basics and Beyond

This book is a comprehensive resource that discusses the multifaceted condition of otitis media. It aims to serve a wide range of medical professionals, including otolaryngologists, audiologists, paediatricians, and medical students, by providing both fundamental knowledge and advanced insights into...

A patient-centred approach from the patient’s point of view

Seeking help for hearing loss is often a big step for patients. Shari Eberts, a hearing health advocate living with hearing loss, explains why, and gives us her five top tips to improve patient-centred care in such cases. Sensorineural hearing...

Hearing loss and Alport syndrome

Alport syndrome (AS) includes a group of hereditary diseases caused by mutations in the COL4A3, COL4A4 or COL4A5 genes. These genes are responsible for the biosynthesis of α3, α4 and α5 collagen IV chains, which are located in the glomerular...

In memory of Robert Allan Yorston (10th March 1920 – 1st October 2016)

In this special feature article, Alan Gibb writes a touching tribute to his friend and colleague Dr Bob Yorston, a Dundee otolaryngologist, who had a special talent for humour and art. In addition to illustrating the eighth, ninth and tenth...

Adjoin™ bone conduction system

Patrik Westerkull (PW), Otorix AB, and Ann-Louise McDermott (A-LM), ENT Consultant at Birmingham Children’s Hospital, tell us about the Adjoin bone conduction device, a non-surgical bone-conduction option developed by Otorix. They explain how the product works, the background to the...

In conversation with Dr John Woo and Mr Derek Skinner

Dr John Woo and Mr Derek Skinner have between them an absolute wealth of experience and expertise in the fields of surgical training and specialist examinations. Here, they tell us about their involvement in surgical education, and explain some of...

JAMA Network Reader

Accessing content from The Journal of the American Medical Association (JAMA) and its nine specialty journals (including JAMA Otolaryngology – Head & Neck Surgery) has now become a bit easier, thanks to an app designed for viewing JAMA articles on...

The ORL App: I challenge you to duel!

'Every day is a school day’ – an age-old saying that is as much a proverb as it is an instruction for allied health professionals. These days, it is hard to keep up with any sort of news - whether...

Audiovisual antics – now you see it, now you don’t

This series of stories is dedicated to those of you with whom some of these moments were shared (or endured) and, above all, to my amazing and long-suffering husband, David Howard. Most of you know him as an exceptional head...