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Bile acids and pharyngeal malignancy
Laryngopharyngeal reflux is a commonly described condition. There is strong evidence linking gastro-oesophageal reflux with oesophageal carcinomas. Gastric refluxate consists of gastric acid, pepsin and bile acids. The roles of pepsin and acidic conditions in the development of laryngopharyngeal carcinoma...
What should be considered a ‘close’ margin in oral cavity squamous cell carcinoma?
Achieving clear margins during surgical resection in oral cavity squamous cell carcinoma (OCSCC) is thought to reduce local recurrence (LR) and improve prognosis; however, what constitutes a clear, close, or involved margin is inconsistent in the literature and in practice....
Paediatric nasopharyngeal carcinoma
Between 11 and 18% of nasopharyngeal carcinomas (NPC) occur in the paediatric age group but there are no specific management guidelines for this age group. Tunisia is a region with an intermediate incidence of NPC, the authors studied 40 cases...
An algorithm to distinguish between distant metastases and metachronous lung primary in patients with HPV-related oropharyngeal cancer
Distinguishing between distant metastases of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) and metachronous primary lung squamous cell carcinoma (SCC) is important as it has implications for treatment, prognosis counselling, and registry data. Although p16 immunohistochemistry (p16 IHC) is widely accepted...
Managing the most common branchial arch anomaly
This article is a well written, helpful summary of the management of the most common branchial anomaly in children – the second. These are characterised as cysts, sinuses or tracts between the anterior border of sternocleidomastoid, coursing between the internal...
Sleep before and after nasal polyposis surgery
This prospective French study looked at the change in nasal symptoms related to sleep, in a questionnaire before and after nasal polyposis surgery. Sixty-three patients who underwent endoscopic sinus surgery completed the DyNaChron questionnaire before, at six weeks and at...
Precision medicine in allergic rhinitis and chronic rhinosinusitis
Precision medicine (PM) with its ‘four Ps’ (personalised, predictive, preventive and participatory) is about appreciating differences between individuals when offering management options for health problems. Multiple groups interested in rhinology such as EPOS and ARIA supported a review of the...
No increase in papillary thyroid cancer during pregnancy
This small study of 19 pregnant patients, who were diagnosed with papillary thyroid cancer before or during the early stages of pregnancy (up to 20 weeks), assessed the changes of thyroid tumours during pregnancy. Conducted at a single centre over...
Healthcare economics and device approvals
We use several FDA-approved devices in our clinical practice but are rarely aware about the stringent procedures followed by manufacturers, as well as the FDA, before the devices become commercially available. The authors of this paper undertook a comprehensive review...
Poor allergic rhinitis control increases the overall costs
Allergic rhinitis and asthma are common and can have significant effects on quality of life. However, not many studies have focused on the economic effects. The authors of this study performed a large-scale (over 60,000 patients) observational study to analyse...
Diagnosis of obstructive sleep apnoea hypopneoa syndrome (OSAHS) without sleep studies
Polysomnography is considered the ‘gold standard’ in the diagnosis of sleep apnoea but it is expensive and difficult to perform in children. Diagnosis based on subjective judgement is often inaccurate. An accurate diagnostic scale based on clinical parameters could obviate...
