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Bile acids and pharyngeal malignancy

Laryngopharyngeal reflux is a commonly described condition. There is strong evidence linking gastro-oesophageal reflux with oesophageal carcinomas. Gastric refluxate consists of gastric acid, pepsin and bile acids. The roles of pepsin and acidic conditions in the development of laryngopharyngeal carcinoma...

Mindfulness meditation versus relaxation therapy for tinnitus

Tinnitus, defined by McFadden as “a conscious experience of sound that originates in the head of its owner, without an external acoustic source”, has a high prevalence and variable psychological impact. It results from maladaptation of the brain to a...

Laryngeal Cancer: Clinical Case-Based Approaches

This book, published by Thieme, provides a lot of information in a compact size. I enjoyed reading the book as it has an international list of authors and contributors from South America, USA, Europe and Asia which gives it an...

Organoids in otolaryngology

This interesting review article summarises the status as well as future prospects of organoid technology in our field. Organoids are a mass of cells which are typically cultured in vitro with 3D technology. They simulate miniature tissues and organs and...

ChatGPT to select patients for biologic therapies in CRSwNP?

This short communication describes programming the artificial intelligence (AI) algorithm for systematic review of current literature about guidelines on the clinical efficacy and safety of biologics in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). The authors first performed...

The microbiological environment of the paranasal sinuses

This article reviews the ecology of the sinuses and tries to make sense of the confusing literature on the subject. This covers the details of molecular studies, particularly those which attempt to differentiate normal sinuses from those in patients with...

Medical trends in sleep disordered breathing

This duo provide an eloquent outline of sleep disordered breathing in general, with particular emphasis on the medical impact and associations of the condition. The increasing prevalence of the condition is described, with increasing worldwide obesity, increased association of cardiac...

Aerosols and polypi

Infection in the operative cavities after endoscopic sinus surgery for sinonasal polyposis leads to recurrence of symptoms and mucopurulent discharge. The usual therapies include systemic antibiotics sometimes with steroids. The authors hypothesised that the use of a topical antimicrobial (tobramycin...

Gene therapy restores baby’s hearing

The guest editor of a forthcoming supplement for ENT & Audiology News has helped enable a baby girl born deaf to hear unaided for the first time.

Harnessing head and neck cancer genomics for personalised medicine

Luc Morris updates us on the future of cancer diagnosis and treatment, which lies in “personalised oncology”, where specific molecular alterations of each tumour will be identified, and matched with actionable alterations in existing therapies, ushering in the era of...

Endotypes in chronic rhinosinusitis: clinical relevance

Identifying endotypes enables personalised therapies that target specific pathophysiological processes, potentially resulting in better treatment outcomes for patients. The contemporary model of chronic rhinosinusitis (CRS) pathogenesis revolving around endotype, in combination with an expanding toolbox of diagnostics and therapeutics, enables...

The power of (younger versus older) lips

The Directional into Velocity of Articulators (DIVA) model theorises that we require both auditory and sensory feedback - from our articulators - in order to ensure we are able to produce precise and powerful articulatory movements. This study aimed to...