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Surviving oropharyngeal squamous cell carcinoma – does subsite matter?

7 January 2020 | | HPV, database, oropharynx, prognosis, tonsil
Human papilloma virus (HPV) status is a known prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC). The eighth edition of American Joint Cancer Committee (AJCC) has modified the TNM staging to reflect this. However, subsite as an independent prognostic factor...

eNOS and OME

1 July 2017 | | Otitis media, Polymorphism of the eNOS, Otitis, serous, Turkey
The pathophysiology of otitis media with effusion (OME) is multifaceted. The authors tackled the nitrous oxide (NO) and platelet activating factor (PAF) pathways and the genetic polymorphism of endothelial nitrous oxide synthetase (eNOS). DNA analysis by PCR and restriction fragment...

Hereditary haemorrhagic telangiectasia

1 November 2015 |
This is a very nicely written overview of this difficult condition by two expert rhinologists with a tertiary practice. The genetic basis, pathophysiology, diagnosis, natural history and available management options are all discussed. Clearly there is a large spectrum of...

Sulcus vocalis in patients attending voice clinics: A retrospective study

1 May 2015 |
Sulcus vocalis was first described by Giacomini. This includes a variety of anatomic indentations of the vocal fold, ranging from shallow longitudinal furrows to deep vocal cord pits. This retrospective study was conducted at King Saud University between 2006 and...

A higher aspiration for fine needles

1 March 2015 | | ENTA-ENT | Indeterminate biopsy, Molecular testing, Thyroid cancer, Thyroid nodule
Fine needle aspiration biopsy (FNAB) has aided in the diagnosis and management of thyroid nodules for decades. Now a rapid evolution is hoped to benefit an increasing cohort of patients with small nodules and non-diagnostic investigations. This review discusses the...

Genetics of IP-III

6 November 2024 | | ENTA-Neurotology, ENTA-Otology
The authors provide a literature review of the genetic basis and clinical features of incomplete partition (IP)-type III. The condition is seen typically in males and is due to mutation in the POU class 3 homeobox 4 (POU3F4) gene which...

The changing landscape for hearing loss therapeutics: novel advances of gene and cell therapies

3 September 2024 | | ENTA-Audiology - Adult
Recent years have seen advances in hearing loss therapeutics, with novel treatments trialled in humans, and others nearing promising first-in-kind clinical trials. First successful clinical trials for a specific form of genetic hearing loss Very exciting news has emerged in...

Imaging tinnitus

1 May 2014 | | ENTA-Audiology - Adult, ENTA-ENT, ENTA-Tinnitus
Tinnitus is a common sensation with a reported prevalence of 7-32%. The British National Study of Hearing recorded that 10% of adults suffered from prolong spontaneous tinnitus, and approximately a quarter of these are subsequently referred to hospital for investigation...

Advances in vestibular function testing

1 November 2015 | | ENTA-ENT, ENTA-Vestibular Disorders
Vestibular function testing has historically been limited by difficulties in testing individual parts of the vestibular apparatus. Jas Sandhu describes new tests available to clinicians that address this problem. Advances in vestibular function testing Vestibular function testing has historically been...

Reducing hierarchy for individuals and teams across ENT

3 May 2022 | | ENTA-ENT
Alexander Pope said that “to err is human”, but medical errors can have serious consequences. How can better communication minimise the risk of them occurring in the first place? Allowing all members of the surgical team to feel empowered to...

A person-centred approach to telehealth

1 March 2017 | | ENTA-Audiology - Adult, ENTA-Audiology - Diagnostic, ENTA-Audiology - Paediatric
“The time when telehealth was a remote, abstract concept has come to an end”. Deborah Ferrari and Lise Lotte Bundesen discuss how to advance person-centred care in hearing rehabilitation through online tools and training. The time when telehealth was a...

The importance of hearing aid validation in infants with hearing loss

31 October 2018 | | ENTA-Audiology - Paediatric
Hearing aid validation requires that speech discrimination be measured, yet there are no validated methods of measuring speech discrimination in infants and toddlers. Prof Uhler describes two related approaches that are showing promise. Speech discrimination is the gold standard for...