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Investigation of the role of KPNA2 biomarker in oral SCC invasiveness
This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...
Is it necessary to put ventilation tubes at the time of surgery in children with cleft palate?
It is commonly understood that existence of a palatal cleft is associated with abnormal action of tensor veli palatini muscle. Frequent middle ear effusions therefore occur because this muscle obstructs rather than opens the Eustachian tube on yawning and swallowing,...
Is it worth paying for group therapy?
Group therapy for post-stroke communication difficulties has been described in the research literature for more than 50 years and is generally considered an efficacious approach. Yet these authors express concern that the American Medicare system is less willing to fund...
Cochlear microphonics in children
Cochlear microphonics (CM) are generated mainly from outer hair cells and are routinely tested in children with hearing loss in some parts of the world. In this retrospective study, the aim was to compare the cochlear microphonics features (mainly CM...
Expanding the role of FNA in thyroid nodule decision-making
Papillary thyroid cancer, the commonest histological type, has been extensively reported as having BRAF proto-oncogene mutations (most commonly the V600E mutation). There is great interest in BRAF as a molecular marker, particularly as a prognostic factor that may guide the...
Inequitable access to cochlear implantation across the UK
Referral rates and uptake of cochlear implantation in the global adult population are low. Five audiology centres across England and Wales retrospectively explored data over a six-month period in late 2019, post implementation of new National Institute for Health and...
Diurnal and monthly variations in secondary post-tonsillectomy haemorrhage rates
Several studies have looked into variable haemorrhagic rates with different methods of surgery and clinical backgrounds. Few have looked into non-clinical factors such as environment and diurnal influence on occurrence of post-tonsillectomy bleeding. This extensive study comprises 5357 tonsillectomy patients...
Can prediction models help identify dysphagia in ventilated patients?
Dysphagia commonly affects patients in intensive care units (ICU), particularly those on mechanical ventilation, and is associated with high risk of mortality. This systematic review and meta-analysis aimed to identify predictors for dysphagia in ventilated ICU patients by summarising existing...
Effectiveness of oral pressure therapy in obstructive sleep apnoea: a systematic analysis
Oral pressure therapy (OPT) is a relatively new form of therapy for obstructive sleep apnoea (OSA). Paradoxically it seems to work even though it creates a vacuum in the oral cavity as opposed to the gold standard of continuous positive...
Practical Neurotology and Skull Base Surgery
The introduction describes this text as being useful for a wide readership including the medical student, physician assistant, nurse practitioner and physical therapist dealing with dizziness. I would be of the opinion as indicated in the preface that this is...
Head injury and prolonged bed rest, but not inner ear disease, predict poorer outcome after Epley manoeuvre in posterior semicircular canal benign paroxysmal positional vertgo (P-BPPV)
This Japanese study included 197 patients with P-BPPV treated over a two and a half year period. The vast majority had idiopathic BPPV (n=157). The remaining 40 had secondary BPPV, eight following head trauma, 14 due to prolonged bed rest...
