You searched for "lesions"
The future of biologics?
This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...
Paediatric vestibular dysfunction
This Malaysian study looked at the awareness amongst otorhinolaryngologists in the investigation and management of paediatric vestibular dysfunction. The authors noted that, although paediatric vestibular dysfunction is a common problem, there seems to be limited literature in assessing the proficiency...
Hurdle jumping
This article deserves a little attention, rather like settling into conversation. As the writers state, listening is an effort and is a tricky field of study when combining multiple physiological measures. In order to gain an understanding, they suggest: consider...
CRSwNP initiation, not always an interleukin fault
CRSwNP, similar to asthma, is an inflammatory disorder (type II) with eosinophilia and raised IL-5 and IL-13. Inflammation in CRSwNP is thought to be started by IL-25, IL-33 and thymic stromal lymphopoietin (TSLP), all of which form an important part...
Semantic fluency test to investigate deaf children
Semantic fluency task (SFT) is used to measure lexical organisation and executive function across the lifespan and requires participants to name examples from a particular semantic category in a specific period of time. Using this test, the authors investigated a...
Allergen specific subcutaneous immunotherapy helps in prolonged control of allergic rhinitis
One of the commonest allergens involved in perennial allergic rhinitis is house dust mite. A good proportion of these cases prove intractable to treatment with oral and intranasal antihistamines and intranasal steroid sprays. Immunotherapy is considered a useful alternative and...
Should we reconsider induction chemotherapy in advanced stage laryngeal cancer?
Use of chemo-radiotherapy for advanced laryngeal cancer led to a major shift in treatment as an alternative to total laryngectomy. Despite widespread adoption of chemoradiotherapy, survival rates have not improved and the original premise of matching neoadjuvant chemotherapy tumour response...
Balloon dilatation is an effective adjunct
This is a good study design, sufficiently powered, comparing medical management to balloon sinus dilatation. All patients had failed medical management and were thoroughly assessed preoperatively with Lund-Mackay score confirming abnormal CT findings, SNOT 20 index score, chronic sinusitis score...
Another use for Tisseel – plugging of the round window
After insertion of a cochlear implant electrode through the round window, there are several methods of sealing the perilymph leak and in my experience fascia (with varying amounts of attached muscle) seems to be most commonly used. Stephen O’Leary’s group...
Role of the insula and orbitofrontal cortex in tinnitus related distress
It is estimated that 5% of the population suffer from chronic tinnitus with 17% of those suffering emotional distress. The authors attempted to study the neural correlates of tinnitus-related distress using functional magnetic resonance imaging (fMRI) during an Emotional Stroop...
A drug to prevent hearing loss caused by ototoxic therapeutics
This editorial briefly highlights the progress made in discovering a compound named ORC-13661, which shows the potential to alter the response of hair cells to ototoxic medication. In the late 1980s, inner hair cells that were lost secondary to noise...
