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OTO-104 in noise-induced and cisplatin-induced hearing loss

These two animal studies report on potential new applications for intra-tympanic OTO-104, a slow-release hydrogel formulation of dexamethasone that is currently being used in a Europe-wide randomised trial for Ménière’s disease. In the first paper, guinea pigs were given a...

Alcohol consumption and the risk of developing benign laryngeal disorders?

Alcohol consumption among South Korean adults is apparently high, with over three quarters of the adult population consuming alcohol and a ‘high-risk’ drinking rate of one in five. Excessive alcohol consumption is considered to be a risk factor for developing...

Newborn sensorineural hearing loss – what is the incidence?

In the last two decades, the introduction of newborn screening for hearing loss has dramatically lowered the average age of newborn hearing loss diagnosis to around two to three months of age. The benefits of early diagnosis are manifold, enabling...

Storytelling is good for your memory

Mild cognitive impairment (MCI) presents a challenging frontier in healthcare due to the limited availability of effective drugs. Despite its prevalence and potential progression to dementia, there remains a notable gap in pharmacological interventions targeting MCI. This month’s Editors’ Choice...

New MRI technique assesses treatment response in skull base osteomyelitis

This paper describes another useful imaging technique to monitor Necrotising Otitis Externa (NOE). Echoplanar diffusion weighted magnetic resonance (DW MR) shows high signal on the ‘ADC map’ with active disease and this reduces in signal intensity as symptoms improve. This...

Spasmodic dysphonia – is greater awareness needed?

Spasmodic dysphonia (SD) is a focal dystonia of the laryngeal musculature. Previously considered to be a rare disorder, it has more recently been suggested that SD is in fact not rare but is frequently misdiagnosed or undiagnosed. This paper would...

Covid-19 and vestibular symptoms review

Since the coronavirus pandemic, there have been several studies looking into alterations within the auditory system but few in the vestibular system associated with Covid-19. This review delves into the specific evidence. It is challenging to elucidate the link between...

Is submandibular gland transfer effective in prevention of post irradiation xerostomia in head and neck cancer patients?

Post irradiation xerostomia is a common side effect of irradiation to the head and neck region, with up to 90% of patients reporting some symptoms. Submandibular glands account for 70% of resting saliva production. Surgically transferring the submandibular gland to...

High dose betahistine as effective as, but slower acting compared to intratympanic dexamethasone in intractable Meniere’s disease

The management of intractable Meniere’s disease poses a complex conundrum to otolaryngologists. The focus of treatment is decreasing the severity and frequency of vertigo and tinnitus whilst trying to preserve hearing. Betahistine has been used for many years in the...