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Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody

Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...

Persistent symptoms of smell loss after COVID-19 infection

Anosmia as a result of COVID-19 infection is well recognised. This timely and topical French paper looks at 115 patients with proven SARS-CoV-2 infection, who were contacted with specific questions about olfactory and gustatory disturbance. They found 81% of patients...

Bone thickness and split pattern in mandibular osteotomies

This paper looked at 63 sagittal split ramus osteotomy sites. The type of split was classified according to the Plooij paper and bone measurements were taken at four sites. Of these sites, the thickness of the bone in one point,...

Going online with dysphagia practice: potential for innovation post pandemic

Telepractice is perhaps the most widespread service innovation to have received such rapid uptake across health systems globally. Disciplines that started to adopt telehealth prior to the pandemic found themselves at the forefront of a seismic shift to delivering healthcare...

The future of biologics?

This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...

Painful temporomandibular joints

This paper is a meta-analysis of randomised controlled trials comparing arthrocentesis with conservative management in painful and restricted mouth opening temporomandibular joint symptoms. Temporomandibular joint dysfunction comprises a spectrum of disorders commonly involving facial pain and loss of oral function...

Vestibular Testing Interpretation: Drill and Practice

My overall impression of this book is that I liked it. While it reports to be designed for a trainee or junior practitioner, it may be useful for clinicians for whom vestibular conditions and testing is an area of heart-sink...

Endoscopic stapes surgery

This retrospective Turkish study looked at the audiological and surgical outcomes of 40 patients who underwent endoscopic stapes surgery over a three-year period. To assess the learning curve, the patients were divided into two groups based on the date of...

Still not smelling

Post-Covid anosmia/hyposmia is a troublesome persistent symptom for lots of patients. Management is still elusive. This was a nationwide survey of ENT practitioners. Of the 715 surveyed members, only 7.4% responded. Most performed a nasal endoscopy, 60% ordered an MRI...

Does transoral robotic surgery improve outcomes among patients with head and neck cancer of unknown primary?

A tonsillectomy and tongue base mucosectomy is becoming increasingly accepted as the optimal surgical intervention to aid in identifying the primary source of a p16+ / HPV-related squamous cell carcinoma (SCC) of unknown origin, given that this disease almost exclusively...

Can ‘cone beam CT scan’ (CBCT) facilitate one-stop rhinology clinic?

Chronic rhinusinusitis can be diagnosed on the basis of its classical symptoms such as nasal obstruction, facial pains, postnasal drip and hyposmia, supported by endoscopic findings such as oedema of middle meatus, mucopus and polyps. However, CT scan findings are...