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The future of inner ear drug delivery

The techniques for delivering drugs to the inner ear system are evolving. Jeffrey Harris considers the myths, the facts and the potential for drug delivery innovations and how they can improve tomorrow’s hearing outcomes. The inner ear’s delicate membranous structure,...

Inner ear immunity

There is much speculation regarding the ear’s immune response. The environment in which we live and breathe is getting ever more complex; aspects such as the percentage of the population with autoimmune conditions are on the rise and, therefore, it...

In this issue...Inner Ear Therapeutics

Emma Stapleton, MBChB, FRCS (ORL-HNS), Consultant Otolaryngologist, Cochlear Implant and Skull Base Surgeon, Manchester Royal Infirmary, UK. E: emmastapleton@doctors.org.ukTwitter: @otolaryngolofox Ralph Holme, Director of Research and Insight, RNID, UK. Ralph. E: Holme@rnid.org.uk W: www.rnid.org.uk For Mar/Apr 2022, we sang the...

Cochlear implantation and inner ear malformations

In this study the authors attempted to compare the outcomes in children who underwent cochlear implantation (CI) with inner ear malformations to those that had normal inner ear anatomy. Sixty three children with prelingual deafness who underwent CI were included....

Microneedles enable inner ear precision medicine

Developing safe, reliable and efficient ways to deliver therapeutics into the cochlea is a key challenge. In this article, the authors share their work to develop microneedles to address this challenge. The era of precision medicine of the inner ear...

Vestibular schwannoma surgery and inner ear injuries

Iatrogenic inner ear injury during vestibular schwannoma (VS) surgery ranges between 20% and 30% in the literature. However, there is no up-to-date quantification of such injuries, hence this study. The authors conducted a US-multicentre database search looking for patients who...

What we need to know about the new frontier of inner ear therapies

This is an interesting and topical review of the emerging biotechnology and pharmaceutical solutions for hearing loss and related conditions such as tinnitus. This paper suggests we are on the cusp of a very large step-change in the way we...

Head injury and prolonged bed rest, but not inner ear disease, predict poorer outcome after Epley manoeuvre in posterior semicircular canal benign paroxysmal positional vertgo (P-BPPV)

This Japanese study included 197 patients with P-BPPV treated over a two and a half year period. The vast majority had idiopathic BPPV (n=157). The remaining 40 had secondary BPPV, eight following head trauma, 14 due to prolonged bed rest...

Team proves secure pathway to the inner ear

An international team of surgeons and scientists has, for the first time, validated safe surgical access to the central core of the human cochlea.

Allergy – what’s in a name?

Allergy is defined as an “abnormal immune reaction to an ordinarily harmless substance” [1], however the meaning of the word has taken many forms since its introduction in 1906 by Austrian Paediatrician and Immunologist, Clemens von Pirquet [2]. Combining his...