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It is not unusual to come across patients with recurrent sinonasal infections, lung infections and recurrent ear infections needing regular antibiotics in the outpatient setting. Physicians need to have a high index of suspicion that patients may have immune deficiency as the underlying cause and investigate/manage them appropriately. Early recognition can prevent long-term sequelae and complications. Treatment should include culture-directed and/or prophylactic antibiotics, immunoglobulin replacement therapy, and FESS when necessary. A multidisciplinary approach between the otolaryngologist and the immunologist is recommended to ensure high-quality care for patients with chronic rhinosinusitis and primary immunodeficiency disorders. I found this paper useful and practical. It is comprehensive and salient features are nicely highlighted.

Immunoglobulin Deficiency and the Unified Airway.
Makary CA, Jang DW, Lugar P.
OTOLARYNGOL CLIN N AM
2023;56(1):97-106.
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Kerri Millward

Manchester Paediatric Cochlear Implant Programme, Manchester, UK.

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Morag Lockley

Manchester Auditory Implant Centre, Manchester, UK.

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