eNOS and OME
Reviewed by Badr Eldin Mostafa

The pathophysiology of otitis media with effusion (OME) is multifaceted. The authors tackled the nitrous oxide (NO) and platelet activating factor (PAF) pathways and the genetic polymorphism of endothelial nitrous oxide synthetase (eNOS). DNA analysis by PCR and restriction fragment length polymorphism (RFLP) was performed for the Glu298Asp simple nucleotide on codon 298. The study was performed on 89 OME patients and 85 matched controls. There were no statistically significant differences between patients and controls for different genotype distributions. However, a statistically significant relationship was observed between allele G and the risk of development of OME. This may be clinically relevant if larger studies are performed on different populations to document this finding. If this eventually proves to be robust it is possible to modify long-term management paradigms for patients with OME.

Les polymorphismes de l’eNOS dans l’otite seromuqueuse.
Ates M, Cevik C, Dokuyuku R, et al.
ANNALES FRANCAISES D’OTO-RHINO-LARYNGOLOGIE ET DE PATHOLOGIE CERVICO-FACIALE
2017;134(1):3-5.