Journal Reviews

Allergy journal cover image.

Eosinophilic or not eosinophilic: dupilumab seems to work

3 May 2022 | | ENTA-ENT | ENT (rhinitis; biologics; eosinophils; inflammation; nasal polyps), sinusitis

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammation with interleukin (IL)-4, IL-13, and IL-5. Tissue eosinophilia in nasal polyps dramatically increased over a 10-20-year period. Classification of the severity of eosinophil status is expected to lead to...

American Journal of Rhinology & Allergy cover image.

Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody

1 July 2021 | | ENTA-Rhinology / Sinus | MLK, SNOT-22, allergic fungal rhinosinusitis, anti-IL-5, asthma, eosinophils, mepolizuma, nucala, prednisone rescue, recalcitrant

Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...

American Journal of Rhinology & Allergy cover image.

Simple preoperative tests predicting outcomes for ESS patients?

4 May 2021 | | ENTA-Rhinology / Sinus | Lund-Kennedy Endoscopic Score, Mometasone Furoate, SNOT-2, chronic rhinosinusitis, disease control, endoscopic sinus surgery, eosinophils, nasal cytology, nasal polyps, neutrophils

We are all familiar with patients suffering extensive nasal polyps who relapse all to soon after careful and thorough endoscopic sinus surgery (ESS). This paper looks to answer whether we can predict which patients will do well, and which less...