ENT features
Discovery in the genetics of complex disease: Otitis media
Otitis media (OM), a common disease of childhood, is considered to be a complex trait with multiple genetic and environmental factors expected to contribute to a child’s risk of developing recurrent acute OM (rAOM; ≥3 episodes in 6 months or...
Assessment of genetic disorders: congenital sensorineural hearing loss
Severe or profound sensorineural hearing impairment (SNHI) is a common birth defect, affecting approximately 1 in 1000 newborns [1]. SNHI may result from environmental causes or have a genetic basis. The genetic causes can be further subdivided into non-syndromic (isolated...
Maxillofacial and neck surgery in Iraq and Afghanistan
Introduction Over the past 150 years, military personnel wounded in action had a survival rate of approximately 80% [1]. During the current conflicts in Iraq and Afghanistan, those servicemen wounded in action have a 90.4% survival rate [2]. During the...
Military otolaryngology and its impact on civilian trauma care
Over the centuries, military conflicts and wars have caused both death and injuries and led to improvements in the care of the combat wounded. Military otolaryngologist-head and neck surgeons have been at the forefront of these developments and advances. War...
Barotrauma
Barotrauma is an injury which is due to the effects of pressure upon an air-containing space. Healthy middle ear cavities and paranasal sinuses are normally in equilibrium with the atmospheric pressure, but if an individual moves away from the surface,...
Effects of blast and acoustic trauma: assessment of hearing status on war veterans
Introduction Acoustical conditions of the military are often dangerous and there is a real risk of blast trauma and acoustic trauma [1, 2]. Levels of military noises maybe reach up to 125 dBA [3]. Weapons produce instant shock waves (10μs)...
Radiology of referred otalgia
Otalgia is a common presenting complaint to Ear Nose and Throat Departments. Otalgia is either primary or secondary (referred) [1]. Referred otalgia is a ‘red flag’ symptom and can be a diagnostic challenge for clinicians and radiologists as the pathology...
Detecting postoperative cholesteatoma with diffusion weighted magnetic resonance imaging
Middle ear cleft cholesteatoma is an inflammatory disease that erodes local bony structures and can cause otorrhea, hearing loss, vertigo and intracranial complications. It is usually treated with surgery, typically canal wall up (CWU) or canal wall down (CWD) surgery....
Pre-clinical development of magnetic delivery of therapy to middle and inner ears
Why are we developing this technology? A key problem in drug delivery is getting the therapy to the right place in the body, which is especially challenging for targets that are small, deep and are protected or surrounded by anatomical...
