Monika Ołdak PhD, Department of Genetics, and Wiktor Jędrzejczak PhD, Department of Experimental Audiology, Institute of Physiology and Pathology of Hearing, Warsaw, Poland
This September, two scientific meetings were held together in Warsaw, Poland: the 59th Inner Ear Biology Workshop and the 7th International Conference on Hyperacusis and Misophonia.
From the perspective of a clinical and laboratory geneticist, IEB2024 revealed several important developments in the field of hereditary hearing loss. One of the highlights was the French practice of performing trio whole genome sequencing (WGS) tests for patients when basic genetic tests fail to yield a diagnosis. This innovative approach reflects the increasing use of high-throughput DNA analysis methods globally, which promises to improve our ability to detect genetic causes of hearing loss, uncover new genes and understand the underlying molecular mechanisms. Another exciting topic was the innovative use of inner ear organoids derived from human induced pluripotent stem cells (hiPSCs) to model genetic hearing disorders caused by mutations in genes such as USH2A and COCH. These organoids accurately replicate the cellular architecture of the inner ear, including otic vesicles, hair cells and periotic mesenchymal cells, providing a valuable platform for testing novel therapies and critical insights into the biological processes underlying genetic hearing loss.
The electrophysiology of hearing was another topic addressed, highlighting significant advancements in auditory science, focusing on the cognitive aspects of hearing, the role of otoacoustic emissions (OAEs) and the effects of chronic electrical stimulation on neural degeneration. Presentations covered various aspects of inner ear biology, including the relationship between hearing loss and cognitive decline, genetic factors in age-related hearing loss, and molecular mechanisms of inner ear development. Researchers discussed novel approaches to preventing and treating hearing loss, such as NOX3 inhibitors and cochlear implantation techniques. The conference also highlighted advancements in auditory diagnostics and measurements, exploring ear impedance, high-frequency thresholds and electrocochleography.
The ICHM7 focused on practical insights enhancing research and clinical practice in hyperacusis and misophonia. New questionnaires were presented as diagnostic tools and methods to enhance patients’ compliance with therapy. Researchers discussed also the possibilities of objective diagnostic methods for misophonia or loudness hyperacusis, such as brain imaging studies, objective behavioral tests, or functional biomarkers. Studies on neurochemical and psychophysiological mechanisms of hyperacusis and misophonia were presented and discussed. Much space was devoted to existing therapies and their effects, highlighting the sparsity of evidence-based treatment approaches and the lack of consensus between the specialists. Quality of life issues were also raised, including patients’ quality of sexual life.
Future meetings:
IEB 2025, Tübingen, Germany, September 13-16, 2025 http://www.innerearbiology.eu/
ICHM8, 2026, https://hashirtinnitusclinic.com/
